Synglet oxygen therapy influence on physical activity of patients suffering from bronchial asthma

Abstract

Objective: To study and analysis of physical activity, assessment of the impact of singlet - oxygen therapy. dysfunction of the cardiorespiratory system during maximal exercise in patients with bronchial asthma persistent disease course. Materials and Methods: The study included 30 patients with persistent disease course. In all patients, the diagnosis of asthma has been installed correctly, confirmed clinically and functionally. As a control, were selected and examined 15 healthy volunteers who had no severe clinically significant pathology, aged on average (45,0 ± 4,2) years. Studies of lung ventilation function performed in all patients according to the analysis of the curve spirogram "flow - volume" forced expiratory and total body plethysmography on the unit «Master Scope» and «MasterScreen BodyDiff» company "Erich Jaeger" (Germany). Indicators of gas composition and acid-base status (CBS) capillary blood was evaluated using the analytical micromethod ABL5 "Radiometer". Diffusion capacity of the lungs was investigated using the module for the study of the diffusion of spirometric lung function "VIASYS Healthcare GmbH". Determination of exercise tolerance, the level of implementation of maximum load, physical activity was performed using ergospirometric cardiorespiratory exercise test. To perform the dosage of exercise used ergometer EP / 2 ("Erich Jaeger", Germany) and Ergoselect 1000 LP Basic auto power dissipation regardless of the speed of pedaling. Statistical data processing was performed using the licensed software products included in the software package Microsoft Office Professional 2000 on a personal computer IBM Celeron in Excel. Results The study found that in patients with persistent asthma current physical activity is reduced, as compared with healthy individuals by 10.5% during exacerbation and 2.5% - in remission. Compliance with the appropriate level of work performed was happening with a tendency to irrational function cardiorespiratory system. Namely, when the maximum effort respiratory system lost the ability to adequately improve pulmonary ventilation and maximum absorb oxygen, which was offset by an increase in respiratory minute volume by increasing the frequency and thus reducing the depth of inhalation and exhalation. In turn, on the part of the cardiovascular system was observed compensatory hyperfunction with a tendency to excessive growth of systolic blood pressure, heart rate, a fall in diastolic blood pressure (to reduce the peripheral circulation and improve microcirculation in the muscles). During the test, for 2-3 minutes, maximum load, in patients with asthma compensation mechanisms rapidly depleted: decreased cardiac output of blood falling systolic pressure and heart rate, etc. All the above changes with a reduction in the functional activity of the cardiorespiratory system when performing maximal exercise require the development of new methods of prevention to reduce the progression of the deterioration of its functioning and to prevent deterioration of activities of daily living and quality of life in patients with asthma. Singlet-oxygen therapy in treatment of asthma gives possibility improve physical activity.